IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.
Source:
E.coli
Synonyms:
AGIF (Adipogenesis inhibitory factor)
AA Sequence:
MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
