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Vildagliptin (LAF-237)

品牌：AG Scientific

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规格：20 mg

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CAS:274901-16-5Formula:C17H25N3O2MW:303.4Appearance:WhitePowder

商品详情参考文献相关资料

A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on b-cells by inhibition of ER stress in a mouse model4. Clinically useful antidiabetic agent.

Vildagliptin increases β cell mass by not only directly affecting cell kinetics but also by indirectly reducing cell apoptosis, oxidative stress and endoplasmic reticulum stress in diabetic mice.

Additional Information

Synonyms	(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237; 2-Pyrrolidinecarbonitrile
Product #	V-2421
CAS #	274901-16-5
Chemical Name	(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile
Formula	C₁₇H₂₅N₃O₂
MW	303.4
Appearance	White Powder
Solubility	May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)
Storage Temp	Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Use	Laboratory chemicals, manufacture of substances.