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SU 11274

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:658084-23-2Formula:C28H30ClN5O4SMW:568.09Appearance:OrangeSolidPurity:98%byHPLC

商品详情参考文献相关资料

A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following ICvalues: Met = 0.02M, Flk = 1.3M, EGFR = >100M, PDGFR = >20M, Tie2 = >100M, c-src = >10M, cdk2 = >10M, and FGFR-1 = 9.7M). Inhibition of the Met kinase activity by SU11274 leads to time- and dose-dependent reduced cell growth and induced G1 cell cycle arrest and apoptosis.

Additional Information

Synonyms	3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
Product #	S-2446
CAS #	658084-23-2
Chemical Name	3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
Formula	C₂₈H₃₀ClN₅O₄S
MW	568.09
Appearance	Orange Solid
Purity	98% by HPLC
Solubility	DMSO (~ 10 mg/ml on warming)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell

Additional Information

MDL Number	MFCD08276928
ChemACX	X1533662-2
InChI	InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
SMILES	CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

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