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Nosiheptide

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:56377-79-8Formula:C51H43N13O12S6MW:1222.4Appearance:YellowsolidPurity:>95%byHPLC

商品详情参考文献相关资料

*Please inquire the availability for this product. Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces, first reported by Japanese researchers in 1970. Unlike other bicyclic thiopeptides such as thiosestrepton, the second macrocyclic ring is linked by relatively fragile lactone and thiolactone bridges to the core cyclic peptide. Nosiheptide has broad spectrum antibacterial activity, and has recently demonstrated a prolonged post-antibiotic effect in both nosocomial and community-acquired MRSA compared with vancomycin. Despite its long history in animal health, nosiheptide has not been extensively studied and is regarded as a "lost antibiotic" largely escaping intensive investigation for human application.

Additional Information

Synonyms	Nosiheptine, Multhiomycin, Primofax, RP 9671
Product #	N-2611
CAS #	56377-79-8
Formula	C₅₁H₄₃N₁₃O₁₂S₆
MW	1222.4
Appearance	Yellow solid
Purity	>95% by HPLC
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Nosiheptide has broad spectrum antibacterial activity

Additional Information

MDL Number	MFCD00867479
InChI	InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)/b23-5-
SMILES	C/C=C\1/c2nc(cs2)C(=O)NC3CC(C(=O)OCc4cccc5c4c(c([nH]5)C(=O)SCC(c6nc(cs6)-c7c(cc(c(n7)c8nc(cs8)C(=O)NC(=C)C(=O)N)O)-c9nc(cs9)C(=O)NC(C(=O)N1)C(C)O)NC(=O)c1csc3n1)C)O

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