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    Anti-FANCL Antibody
    品牌：Antibodies
    货号：
    规格：100µg
    货期：
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    Anti-FANCL Antibody
    商品详情 参考文献 相关资料
    Name: Anti-FANCL Antibody
    See all FANCL primary antibodies
    Description: Goat polyclonal antibody to FANCL.
    Applications: ELISA, WB
    Reactivity: Human
    Immunogen: Synthetic peptide corresponding to Human FANCL (internal region).
    Sequence: C-QNLKDVLEIDFP
    Host: Goat
    Clonality: Polyclonal
    Isotype: IgG
    Conjugate: Unconjugated
    Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    Concentration: 100 µg at 0.5 mg/ml.
    Product Form: Liquid
    Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
    Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    Function: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
    Involvement in Disease: Fanconi anemia complementation group L: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Post-Translational Modification: The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.
    Cellular locations: Cytoplasm. Nucleus.
    Database Links:
  2. Entrez Gene: 55120 Human
  3. Omim: 608111 Human
  4. SwissProt: Q9NW38 Human
  5. Unigene: 631890 Human
    		6.
    Synonyms:
  6. E3 ubiquitin-protein ligase FANCL Antibody
  7. FAAP43 Antibody
  8. FANCL Antibody
  9. FANCL_HUMAN Antibody
  10. Fanconi anemia complementation group L Antibody
  11. Fanconi anemia group L protein Antibody
  12. Fanconi anemia-associated polypeptide of 43 kDa Antibody
  13. FLJ10335 Antibody
  14. PHD finger protein 9 Antibody
  15. PHF9 Antibody
  16. POG Antibody
  17. Ubiquitin ligase protein FANCL Antibody
    		18.
    Information: Target information shown above is from the UniProt Consortium.
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