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Anti-erbB-2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-erbB-2 Antibody

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Overview

Name:	Anti-erbB-2 Antibody See all erbB2 primary antibodies
Description:	Chicken polyclonal antibody to erbB-2
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 19 amino acid peptide near the carboxy terminus of human erbB-2.
Host:	Chicken
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification:	Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1250. Dephosphorylated by PTPN12.
Cellular locations:	Cell membrane. Cytoplasm > Perinuclear region. Nucleus.
Database Links:	Entrez Gene: 2064?Human Entrez Gene: 13866?Mouse Entrez Gene: 24337?Rat Omim: 164870?Human SwissProt: P04626?Human SwissProt: P70424?Mouse SwissProt: P06494?Rat Unigene: 446352?Human Unigene: 290822?Mouse Unigene: 93966?Rat
Synonyms:	Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody C erb B2/neu protein Antibody CD340 Antibody CD340 antigen Antibody Cerb B2/neu protein Antibody CerbB2 Antibody Erb b2 receptor tyrosine kinase 2 Antibody ErbB 2 Antibody ERBB2 Antibody ERBB2_HUMAN Antibody HER 2 Antibody HER 2/NEU Antibody HER2 Antibody Herstatin Antibody Human epidermal growth factor receptor 2 Antibody Metastatic lymph node gene 19 protein Antibody MLN 19 Antibody MLN19 Antibody NEU Antibody NEU proto oncogene Antibody Neuro/glioblastoma derived oncogene homolog Antibody Neuroblastoma/glioblastoma derived oncogene homolog Antibody NGL Antibody p185erbB2 Antibody Proto-oncogene c-ErbB-2 Antibody Proto-oncogene Neu Antibody Receptor tyrosine-protein kinase erbB-2 Antibody TKR1 Antibody Tyrosine kinase type cell surface receptor HER2 Antibody Tyrosine kinase-type cell surface receptor HER2 Antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 Antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) Antibody V erb b2 avian erythroblastic leukemia viral oncoprotein 2 Antibody V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody
Information:	Target information shown above is from the UniProt Consortium.