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Anti-Ephrin A1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Ephrin A1 Antibody

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Overview

Name:	Anti-Ephrin A1 Antibody See all Ephrin A1 primary antibodies
Description:	Rabbit polyclonal antibody to Ephrin A1
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:500
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 178 of Ephrin A1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Predicted MW:	24kd
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Tissue Specificity:	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Sequence Similarities:	Belongs to the ephrin family.
Post-Translational Modification:	Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 1942?Human Omim: 191164?Human SwissProt: P20827?Human Unigene: 516664?Human
Synonyms:	B61 Antibody ECKLG Antibody EFL 1 Antibody EFL1 Antibody EFNA 1 Antibody Efna1 Antibody EFNA1_HUMAN Antibody EPH related receptor tyrosine kinase ligand 1 Antibody EPH-related receptor tyrosine kinase ligand 1 Antibody Ephrin A1 Antibody Ephrin-A1 Antibody Ephrin-A1, secreted form Antibody EphrinA1 Antibody EPLG 1 Antibody EPLG1 Antibody Immediate early response protein B61 Antibody LERK 1 Antibody LERK-1 Antibody LERK1 Antibody Ligand of eph related kinase 1 Antibody OTTHUMP00000033242 Antibody OTTHUMP00000033271 Antibody secreted form Antibody TNF alpha-induced protein 4 Antibody TNFAIP 4 Antibody TNFAIP4 Antibody Tumor necrosis factor alpha induced protein 4 Antibody Tumor necrosis factor alpha-induced protein 4 Antibody
Information:	Target information shown above is from the UniProt Consortium.