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Anti-EIF6 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-EIF6 Antibody

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Overview

Name:	Anti-EIF6 Antibody See all EIF6 primary antibodies
Description:	Rabbit polyclonal antibody to EIF6
Specificity:	The antibody detects endogenous level of total EIF6 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EIF6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
Tissue Specificity:	Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
Sequence Similarities:	Belongs to the eIF-6 family.
Post-Translational Modification:	Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.
Cellular locations:	Cytoplasm. Nucleus > Nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.
Database Links:	Entrez Gene: 3692?Human Entrez Gene: 16418?Mouse Entrez Gene: 305506?Rat Omim: 602912?Human SwissProt: P56537?Human SwissProt: O55135?Mouse SwissProt: Q3KRD8?Rat Unigene: 654848?Human Unigene: 271674?Mouse Unigene: 190833?Rat
Synonyms:	b(2)gcn Antibody B(2)GCN homolog Antibody B4 integrin interactor Antibody Binding protein of beta-4 integrin Antibody CAB Antibody eIF-6 Antibody EIF3A Antibody EIF6 Antibody Eukaryotic translation initiation factor 3A Antibody Eukaryotic translation initiation factor 6 Antibody IF6_HUMAN Antibody Integrin beta 4 binding protein Antibody ITGB4BP Antibody OK/SW-cl.27 Antibody p27 beta 4 integrin binding protein Antibody p27(BBP) Antibody p27BBP Antibody RP4-614O4.1 Antibody
Information:	Target information shown above is from the UniProt Consortium.