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Anti-DNAJA1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DNAJA1 Antibody

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Overview

Name:	Anti-DNAJA1 Antibody See all DNAJA1 primary antibodies
Description:	Rabbit polyclonal antibody to DNAJA1
Specificity:	The antibody detects endogenous levels of total DNAJA1 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human DnaJ (Hsp40) homolog, subfamily A, member 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.8mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocations of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
Tissue Specificity:	Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.
Cellular locations:	Membrane. Cytoplasm. Microsome. Nucleus. Cytoplasm > Perinuclear region. Mitochondrion. Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei.
Database Links:	Entrez Gene: 3301?Human Omim: 602837?Human SwissProt: P31689?Human Unigene: 445203?Human
Synonyms:	DJ 2 Antibody DJ2 Antibody DjA1 Antibody DnaJ (Hsp40) homolog, subfamily A, member 1 Antibody DnaJ homolog subfamily A member 1 Antibody DnaJ protein homolog 2 Antibody DNAJ2 Antibody Dnaja1 Antibody DNJA1_HUMAN Antibody hDJ 2 Antibody HDJ-2 Antibody HDJ2 Antibody Heat shock 40 kDa protein 4 Antibody heat shock protein DNAJ like 2 Antibody Heat shock protein J2 Antibody HSDJ Antibody HSJ-2 Antibody HSJ2 Antibody HSPF4 Antibody Human DnaJ protein 2 Antibody NEDD7 Antibody Neural precursor cell expressed developmentally down regulated 7 Antibody OTTHUMP00000021193 Antibody
Information:	Target information shown above is from the UniProt Consortium.