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Anti-CYP21A2 (F177) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CYP21A2 (F177) Antibody

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Overview

Name:	Anti-CYP21A2 (F177) Antibody See all CYP21A2 primary antibodies
Description:	Rabbit polyclonal antibody to CYP21A2 (F177)
Specificity:	CYP21A2 (F177) pAb detects endogenous levels of CYP21A2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 141-190 of Human CYP21A2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 55 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).
Involvement in Disease:	Adrenal hyperplasia 3: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short ***** stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosesynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic).
Sequence Similarities:	Belongs to the cytochrome P450 family.
Cellular locations:	Endoplasmic reticulum membrane. Microsome membrane.
Database Links:	Entrez Gene: 1589?Human Omim: 613815?Human SwissProt: P08686?Human Unigene: 654479?Human
Synonyms:	CYP21 Antibody 21 OHase Antibody 21-OHase Antibody CA21H Antibody CAH1 Antibody CP21A_HUMAN Antibody CPS1 Antibody CYP21A 2 Antibody CYP21A2 Antibody CYP21B Antibody Cytochrome P-450c21 Antibody Cytochrome P450 21 Antibody Cytochrome P450 C21B Antibody Cytochrome P450 XXI Antibody Cytochrome P450, family 21, subfamily A, polypeptide 2 Antibody Cytochrome P450, subfamily XXIA (steroid 21 hydroxylase, congenital adrenal hyperplasia), polypeptide 2 Antibody Cytochrome P450-C21 Antibody Cytochrome P450-C21B Antibody P450 C21 Antibody P450 C21B Antibody P450c21B Antibody Steroid 21 hydroxylase Antibody Steroid 21 monooxygenase Antibody Steroid 21-hydroxylase Antibody
Information:	Target information shown above is from the UniProt Consortium.