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Anti-cTnI Antibody (HRP)

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

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Anti-cTnI Antibody (HRP)

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Overview

Name:	Anti-cTnI Antibody (HRP) See all cTnI primary antibodies
Description:	Mouse monoclonal (KT142) antibody to cTnI (HRP).
Applications:	WB, sELISA
Reactivity:	Human
Immunogen:	Purified human cardiac troponin I.
Host:	Mouse
Clonality:	Monoclonal
Clone:	KT142
Isotype:	IgG1
Conjugate:	HRP
Purification:	IgG is purified through a Protein A column and labelled with horseradish peroxidase.
Concentration:	1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 0.01% Thimerosal.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Involvement in Disease:	Cardiomyopathy, familial hypertrophic 7: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Cardiomyopathy, familial restrictive 1: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. Cardiomyopathy, dilated 2A: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Cardiomyopathy, dilated 1FF: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Sequence Similarities:	Belongs to the troponin I family.
Post-Translational Modification:	Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Database Links:	Entrez Gene: 7137 Human Omim: 191044 Human SwissProt: P19429 Human Unigene: 709179 Human
Synonyms:	cardiac muscle Antibody Cardiac Troponin I Antibody cardiomyopathy, dilated 2A (autosomal recessive) Antibody Cardiomyopathy, familial hypertrophic, 7, included Antibody CMD1FF Antibody CMD2A Antibody CMH7 Antibody cTnI Antibody Familial hypertrophic cardiomyopathy 7 Antibody MGC116817 Antibody RCM1 Antibody Tn1 Antibody Tni Antibody TNN I3 Antibody TNNC 1 Antibody TNNC1 Antibody TNNI3 Antibody TNNI3_HUMAN Antibody Troponin I Antibody Troponin I cardiac Antibody Troponin I cardiac muscle Antibody Troponin I cardiac muscle isoform Antibody Troponin I type 3 cardiac Antibody troponin I, cardiac 3 Antibody TroponinI Antibody Ttroponin I type 3 (cardiac) Antibody
Information:	Target information shown above is from the UniProt Consortium.