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Anti-CRF-RII Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

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Anti-CRF-RII Antibody

商品详情参考文献相关资料

Name:	Anti-CRF-RII Antibody See all CRF-RII primary antibodies
Description:	Rabbit polyclonal antibody to CRF-RII
Specificity:	CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein.
Applications:	WB, IF, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the Internal region of human CRF-RII.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20˚C / 1 year

Function:	G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Sequence Similarities:	Belongs to the G-protein coupled receptor 2 family.
Post-Translational Modification:	A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
Cellular locations:	Cell membrane.