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Anti-Collagen XVII Antibody

品牌：Antibodies

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规格：100µl

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Anti-Collagen XVII Antibody

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Overview

Name:	Anti-Collagen XVII Antibody See all Collagen XVII primary antibodies
Description:	Rabbit monoclonal antibody to Collagen XVII.
Applications:	WB, IHC, IF, IP
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IP: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human COL17A1.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
Tissue Specificity:	Detected in skin (PubMed:8618013). In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) (PubMed:25676728). Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.
Involvement in Disease:	Generalized atrophic benign epidermolysis bullosa: A non-lethal, ***** form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. Epithelial recurrent erosion dystrophy: A corneal dystrophy characterized by recurrent episodes of epithelial erosions from childhood, with occasional impairment of vision. Most patients have attacks of redness, photophobia, epiphora, and ocular pain. Exposure to sunlight or draught, dust and smoke and lack of sleep can precipitate attacks.
Post-Translational Modification:	The intracellular/endo domain is disulfide-linked.
Cellular locations:	Cell junction > Hemidesmosome. Membrane. Localized along the plasma membrane of the hemidesmosome.
Database Links:	Entrez Gene: 1308?Human Entrez Gene: 12821?Mouse Entrez Gene: 294027?Rat Omim: 113811?Human SwissProt: Q9UMD9?Human SwissProt: Q07563?Mouse Unigene: 117938?Human Unigene: 1225?Mouse Unigene: 40392?Rat
Synonyms:	180 kDa bullous pemphigoid antigen 2 Antibody Alpha 1 type XVII collagen Antibody BA16H23.2 Antibody BP 180 Antibody BP180 Antibody BPA 2 Antibody BPAG 2 Antibody BPAG2 Antibody Bullous pemphigoid antigen 2 Antibody COL17A1 Antibody Collagen 17 Antibody Collagen alpha 1 XVII chain Antibody Collagen alpha 1(XVII) chain Antibody Collagen alpha1 XVII chain Antibody Collagen type XVII alpha 1 Antibody Collagen XVII Antibody Collagen XVII alpha 1 polypeptide Antibody CollagenXVII Antibody Epidermolysis bullosa junctional localisata variant Antibody FLJ60881 Antibody KIAA0204 Antibody LAD 1 Antibody LAD1 Antibody
Information:	Target information shown above is from the UniProt Consortium.