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 Anti-CDK12 Antibody |产品详情|进口榴莲视频免费观看采购网


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    Anti-CDK12 Antibody
    品牌：Antibodies
    货号：
    规格：100µl
    货期：

    Anti-CDK12 Antibody
    商品详情 参考文献 相关资料
    Name: Anti-CDK12 Antibody
    See all CDK12 primary antibodies
    Description: Rabbit polyclonal antibody to CDK12
    Specificity: The antibody detects endogenous levels of total CDK12 protein.
    Applications: IHC
    Reactivity: Human
    Immunogen: Synthetic peptide corresponding to residues near the C terminal of human cyclin-dependent kinase 12
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Purification: Antigen affinity purification.
    Concentration: 3.1mg / ml
    Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
    Storage: Store at -20?C
    Function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
    Tissue Specificity: Ubiquitously expressed.
    Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Post-Translational Modification: Phosphorylation at Thr-893 increases kinase activity.
    Cellular locations: Nucleus. Nucleus speckle.

    Colocalized with nuclear speckles throughout interphase.
    Database Links:
  2. Entrez Gene: 51755?Human
  3. Omim: 615514?Human
  4. SwissProt: Q9NYV4?Human
  5. Unigene: 416108?Human
    		6.
    Synonyms:
  6. arginine/serine-rich Antibody
  7. Cdc2 related kinase arginine/serine rich Antibody
  8. CDC2 related protein kinase 7 Antibody
  9. Cdc2-related kinase Antibody
  10. CDC2-related protein kinase 7 Antibody
  11. Cdk12 Antibody
  12. CDK12_HUMAN Antibody
  13. Cell division cycle 2 related protein kinase 7 Antibody
  14. Cell division cycle 2-related protein kinase 7 Antibody
  15. Cell division protein kinase 12 Antibody
  16. CRK7 Antibody
  17. CRKR Antibody
  18. CrkRS Antibody
  19. Cyclin-dependent kinase 12 Antibody
  20. EC 2.7.11.22 Antibody
  21. hCDK12 Antibody
  22. kiaa0904 Antibody
  23. Pksc Antibody
    		24.
    Information: Target information shown above is from the UniProt Consortium.
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