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Anti-CCR5 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCR5 Antibody

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Overview

Name:	Anti-CCR5 Antibody See all CCR5 primary antibodies
Description:	Rabbit polyclonal antibody to CCR5
Applications:	E, WB, IHC
Reactivity:	Human
Immunogen:	Raised against a peptide corresponding to amino acids 6 to 20 of human CCR5.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	DEAE purified
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Tissue Specificity:	Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Involvement in Disease:	Diabetes mellitus, insulin-dependent, 22: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification:	Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 1234?Human Omim: 601373?Human SwissProt: P51681?Human Unigene: 450802?Human
Synonyms:	AM4 7 Antibody C C chemokine receptor type 5 Antibody C C CKR 5 Antibody C-C chemokine receptor type 5 Antibody C-C CKR-5 Antibody C-C motif chemokine receptor 5 A159A Antibody CC Chemokine Receptor 5 Antibody CC Chemokine Receptor Type 5 Antibody CC CKR 5 Antibody CC-CKR-5 Antibody CCCKR 5 Antibody CCCKR5 Antibody CCR 5 Antibody CCR-5 Antibody CCR5 Antibody CCR5 chemokine (C C motif) receptor 5 Antibody CCR5_HUMAN Antibody CD 195 Antibody CD195 Antibody CD195 Antigen Antibody Chemokine C C motif receptor 5 Antibody Chemokine receptor CCR5 Antibody CHEMR13 Antibody CKR 5 Antibody CKR5 Antibody CMKBR 5 Antibody CMKBR5 Antibody FLJ78003 Antibody HIV 1 Fusion Coreceptor Antibody HIV-1 fusion coreceptor Antibody HIV1 fusion coreceptor Antibody IDDM22 Antibody MIP-1 alpha receptor Antibody
Information:	Target information shown above is from the UniProt Consortium.