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Anti-CACNA1S Antibody

品牌：Antibodies

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规格：100µl

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Anti-CACNA1S Antibody

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Overview

Name:	Anti-CACNA1S Antibody See all CACNA1S primary antibodies
Description:	Rabbit polyclonal antibody to CACNA1S
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 544 and 855 of CACNA1S
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 1XPBS, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Tissue Specificity:	Skeletal muscle specific.
Involvement in Disease:	Periodic paralysis hypokalemic 1: An autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. Malignant hyperthermia 5: Autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants. Thyrotoxic periodic paralysis 1: A sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease.
Sequence Similarities:	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.
Post-Translational Modification:	The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690.
Cellular locations:	Cell membrane > Sarcolemma. Detected on T-tubules (extensions of the sarcolemma).
Database Links:	Entrez Gene: 779?Human Omim: 114208?Human SwissProt: Q13698?Human Unigene: 1294?Human
Synonyms:	alpha-1 polypeptide Antibody CAC1S_HUMAN Antibody CACH1 Antibody Cach1b Antibody CACN1 Antibody CACNA1S Antibody CACNL1A3 Antibody Calcium channel Antibody Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal Antibody Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle Antibody Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, hypokalemic periodic paralysis Antibody Calcium channel, skeletal muscle dihydropyridine sensitive , alpha 1 subunit Antibody Calcium channel, voltage dependent, L type, alpha 1S subunit Antibody Calcium channel, voltage-dependent, L type, alpha 1S subunit, b Antibody Cav1.1 Antibody CCHL1A3 Antibody Dihydropyridine receptor Antibody Dihydropyridine sensitive L type calcium channel alpha 1 subunit Antibody fmd Antibody HOKPP Antibody HypoPP Antibody isoform 3 Antibody L type Antibody Malignant hyperthermia susceptibility 5 Antibody mdg Antibody MHS5 Antibody ROB1 Antibody sj Antibody skeletal muscle Antibody TTPP1 Antibody Voltage gated calcium channel subunit alpha Cav1.1 Antibody Voltage-dependent L-type calcium channel subunit alpha-1S Antibody Voltage-gated calcium channel subunit alpha Cav1.1 Antibody
Information:	Target information shown above is from the UniProt Consortium.