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Anti-ATG4B Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-ATG4B Antibody

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Overview

Name:	Anti-ATG4B Antibody See all ATG4B primary antibodies
Description:	Rabbit polyclonal antibody to ATG4B
Specificity:	The antibody detects endogenous levels of total ATG4B protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human ATG4B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Tissue Specificity:	Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Sequence Similarities:	Belongs to the peptidase C54 family.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 23192?Human Entrez Gene: 66615?Mouse Omim: 611338?Human SwissProt: Q9Y4P1?Human SwissProt: Q8BGE6?Mouse Unigene: 283610?Human Unigene: 29087?Mouse
Synonyms:	APG4 autophagy 4 homolog B Antibody APG4B Antibody ATG4 autophagy related 4 homolog B (S. cerevisiae) Antibody ATG4B Antibody ATG4B_HUMAN Antibody AUT like 1 cysteine endopeptidase Antibody AUT-like 1 cysteine endopeptidase Antibody AUTL1 Antibody Autophagin 1 Antibody Autophagin-1 Antibody Autophagy related 4B cysteine peptidase Antibody Autophagy related cysteine endopeptidase 1 Antibody Autophagy related protein 4 homolog B Antibody Autophagy-related cysteine endopeptidase 1 Antibody Autophagy-related protein 4 homolog B Antibody Cysteine protease ATG4B Antibody hAPG4B Antibody MGC1353 Antibody
Information:	Target information shown above is from the UniProt Consortium.