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Anti-ATG12 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATG12 Antibody

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Name:	Anti-ATG12 Antibody See all ATG12 primary antibodies
Description:	Rabbit polyclonal antibody to ATG12
Specificity:	The antibody detects endogenous levels of total ATG12 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3.3mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the ATG12 family.
Post-Translational Modification:	Acetylated by EP300.
Cellular locations:	Cytoplasm. Preautophagosomal structure membrane. TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Database Links:	Entrez Gene: 9140?Human Omim: 609608?Human SwissProt: O94817?Human Unigene: 264482?Human
Synonyms:	Apg12 Antibody APG12-like Antibody APG12L Antibody ATG12 Antibody ATG12 autophagy related 12 homolog Antibody ATG12 autophagy related 12 homolog (S. cerevisiae) Antibody ATG12_HUMAN Antibody Autophagy 12 Antibody Autophagy-related protein 12 Antibody FBR93 Antibody HAPG12 Antibody Ubiquitin-like protein ATG12 Antibody
Information:	Target information shown above is from the UniProt Consortium.