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Anti-PNP Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

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Anti-PNP Antibody

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Overview

Name:	Anti-PNP Antibody See all Nucleoside phosphorylase primary antibodies
Description:	Goat polyclonal antibody to PNP.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human PNP (internal region).
Sequence:	C-SGQNPLRGPNDE
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Tissue Specificity:	Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
Involvement in Disease:	Purine nucleoside phosphorylase deficiency: A disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.
Sequence Similarities:	Belongs to the PNP/MTAP phosphorylase family.
Cellular locations:	Cytoplasm > Cytoskeleton. Cytoplasm.
Database Links:	Entrez Gene: 4860 Human Omim: 164050 Human SwissProt: P00491 Human Unigene: 75514 Human
Synonyms:	FLJ94043 Antibody FLJ97288 Antibody FLJ97312 Antibody Inosine phosphorylase Antibody Inosine-guanosine phosphorylase Antibody MGC117396 Antibody MGC125915 Antibody MGC125916 Antibody NP Antibody Np1 Antibody Nucleoside phosphorylase Antibody PNP Antibody Pnp1 Antibody PNPH_HUMAN Antibody PRO1837 Antibody PUNP Antibody Purine nucleoside orthophosphate ribosyltransferase Antibody Purine nucleoside phosphorylase Antibody Purine nucleoside phosphorylase 5a Antibody
Information:	Target information shown above is from the UniProt Consortium.