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 Anti-Smad1 (P457) Antibody |产品详情|进口榴莲视频免费观看采购网


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    Anti-Smad1 (P457) Antibody
    品牌：Antibodies
    货号：
    规格：50µl
    货期：

    Anti-Smad1 (P457) Antibody
    商品详情 参考文献 相关资料
    Name: Anti-Smad1 (P457) Antibody
    See all Smad1 primary antibodies
    Description: Rabbit polyclonal antibody to Smad1 (P457)
    Specificity: Smad1 (P457) pAb detects endogenous levels of Smad1 protein.
    Applications: WB, IHC
    Reactivity: Human, Mouse, Rat
    Immunogen: Synthetic peptide, corresponding to amino acids 424-478 of Human Smad1.
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Molecular Weight: ~ 60 kDa
    Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
    Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
    Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
    Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.
    Sequence Similarities: Belongs to the dwarfin/SMAD family.
    Post-Translational Modification: Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4.
    Cellular locations: Cytoplasm. Nucleus.

    Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271).
    Database Links:
  2. Entrez Gene: 4086?Human
  3. Entrez Gene: 17125?Mouse
  4. Entrez Gene: 25671?Rat
  5. Omim: 601595?Human
  6. SwissProt: Q15797?Human
  7. SwissProt: P70340?Mouse
  8. SwissProt: P97588?Rat
  9. Unigene: 604588?Human
  10. Unigene: 223717?Mouse
  11. Unigene: 10635?Rat
    		12.
    Synonyms:
  12. BSP-1 Antibody
  13. BSP1 Antibody
  14. HsMAD1 Antibody
  15. JV4-1 Antibody
  16. JV41 Antibody
  17. MAD homolog 1 Antibody
  18. MAD mothers against decapentaplegic homolog 1 Antibody
  19. Mad related protein 1 Antibody
  20. Mad-related protein 1 Antibody
  21. MADH1 Antibody
  22. MADR1 Antibody
  23. Mothers against decapentaplegic homolog 1 Antibody
  24. Mothers against DPP homolog 1 Antibody
  25. SMA- AND MAD-RELATED PROTEIN 1 Antibody
  26. SMAD 1 Antibody
  27. SMAD family member 1 Antibody
  28. SMAD mothers against DPP homolog 1 Antibody
  29. Smad1 Antibody
  30. SMAD1_HUMAN Antibody
  31. TGF beta signaling protein 1 Antibody
  32. Transforming growth factor-beta-signaling protein 1 Antibody
    		33.
    Information: Target information shown above is from the UniProt Consortium.
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