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Anti-SH2D1A Antibody

品牌：Antibodies

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规格：50µl

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Anti-SH2D1A Antibody

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Overview

Name:	Anti-SH2D1A Antibody See all SH2D1A primary antibodies
Description:	Rabbit polyclonal antibody to SH2D1A
Specificity:	SH2D1A pAb detects endogenous levels of SH2D1A protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human SH2D1A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 14 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Tissue Specificity:	Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
Involvement in Disease:	Lymphoproliferative syndrome, X-linked, 1: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 4068?Human Entrez Gene: 20400?Mouse Entrez Gene: 501502?Rat Omim: 300490?Human SwissProt: O60880?Human SwissProt: O88890?Mouse SwissProt: B2RZ59?Rat Unigene: 349094?Human Unigene: 441197?Mouse Unigene: 12605?Rat
Synonyms:	DSHP Antibody Duncan disease SH2 protein Antibody Duncan disease SH2-protein Antibody EBVS Antibody IMD5 Antibody LYP Antibody MTCP1 Antibody SAP Antibody SAP/SH2D1A Antibody SH2 domain containing 1A Antibody SH2 domain protein 1A Antibody SH2 domain-containing protein 1A Antibody SH21A_HUMAN Antibody SH2D1A Antibody SH2D1A/SAP Antibody Signaling lymphocyte activation molecule associated protein Antibody Signaling lymphocytic activation molecule-associated protein Antibody SLAM associated protein Antibody SLAM associated protein/SH2 domain protein 1A Antibody SLAM-associated protein Antibody T cell signal transduction molecule SAP Antibody T-cell signal transduction molecule SAP Antibody XLP Antibody XLPD Antibody
Information:	Target information shown above is from the UniProt Consortium.