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Anti-SETMAR Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-SETMAR Antibody

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Overview

Name:	Anti-SETMAR Antibody See all SETMAR primary antibodies
Description:	Rabbit polyclonal antibody to SETMAR
Specificity:	The antibody detects endogenous levels of total SETMAR protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein of human SETMAR
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).
Tissue Specificity:	Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
Sequence Similarities:	In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily.
Post-Translational Modification:	Methylated. Methylation regulates activity in DNA decatenation.
Cellular locations:	Nucleus. Chromosome. Recruited on damaged DNA at sites of double-strand breaks.
Database Links:	Entrez Gene: 6419?Human Omim: 609834?Human SwissProt: Q53H47?Human Unigene: 475300?Human Unigene: 716054?Human
Synonyms:	Histone lysine N methyltransferase Antibody Histone lysine N methyltransferase SETMAR Antibody Hsmar 1 Antibody Hsmar1 Antibody Mariner transposase Hsmar1 Antibody Metnase Antibody SET domain and mariner transposase fusion Antibody SET domain and mariner transposase fusion gene Antibody SET domain and mariner transposase fusion gene containing protein Antibody SET domain and mariner transposase fusion gene-containing protein Antibody SETMAR Antibody SETMR_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.