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Anti-RUNX1 (T270) Antibody |产品详情|进口榴莲视频免费观看采购网


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    Anti-RUNX1 (T270) Antibody
    品牌：Antibodies
    货号：
    规格：50µl
    货期：

    Anti-RUNX1 (T270) Antibody
    商品详情 参考文献 相关资料
    Name: Anti-RUNX1 (T270) Antibody
    See all RUNX1 primary antibodies
    Description: Rabbit polyclonal antibody to RUNX1 (T270)
    Specificity: RUNX1 (T270) pAb detects endogenous levels of RUNX1 protein.
    Applications: WB, IHC
    Reactivity: Human, Mouse, Rat
    Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human RUNX1.
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Molecular Weight: ~ 55 kDa
    Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
    Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
    Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
    Tissue Specificity: Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
    Involvement in Disease: Familial platelet disorder with associated myeloid malignancy: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
    Post-Translational Modification: Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
    Cellular locations: Nucleus.
    Database Links:
  2. Entrez Gene: 861?Human
  3. Entrez Gene: 12394?Mouse
  4. Entrez Gene: 50662?Rat
  5. Omim: 151385?Human
  6. SwissProt: Q01196?Human
  7. SwissProt: Q03347?Mouse
  8. SwissProt: Q63046?Rat
  9. Unigene: 149261?Human
  10. Unigene: 612648?Human
  11. Unigene: 4081?Mouse
  12. Unigene: 470227?Mouse
  13. Unigene: 11201?Rat
    		14.
    Synonyms:
  14. Acute myeloid leukemia 1 Antibody
  15. Acute myeloid leukemia 1 protein Antibody
  16. alpha subunit core binding factor Antibody
  17. AML 1 Antibody
  18. AML1 Antibody
  19. AML1 EVI 1 Antibody
  20. AML1 EVI 1 fusion protein Antibody
  21. Aml1 oncogene Antibody
  22. AMLCR 1 Antibody
  23. AMLCR1 Antibody
  24. CBF alpha 2 Antibody
  25. CBF-alpha-2 Antibody
  26. CBFA 2 Antibody
  27. CBFA2 Antibody
  28. Core binding factor alpha 2 subunit Antibody
  29. Core binding factor runt domain alpha subunit 2 Antibody
  30. Core-binding factor subunit alpha-2 Antibody
  31. EVI 1 Antibody
  32. EVI1 Antibody
  33. HGNC Antibody
  34. Oncogene AML 1 Antibody
  35. Oncogene AML-1 Antibody
  36. OTTHUMP00000108696 Antibody
  37. OTTHUMP00000108697 Antibody
  38. OTTHUMP00000108699 Antibody
  39. OTTHUMP00000108700 Antibody
  40. OTTHUMP00000108702 Antibody
  41. PEA2 alpha B Antibody
  42. PEA2-alpha B Antibody
  43. PEBP2 alpha B Antibody
  44. PEBP2-alpha B Antibody
  45. PEBP2A2 Antibody
  46. PEBP2aB Antibody
  47. Polyomavirus enhancer binding protein 2 alpha B subunit Antibody
  48. Polyomavirus enhancer-binding protein 2 alpha B subunit Antibody
  49. Run1 Antibody
  50. Runt related transcription factor 1 Antibody
  51. Runt-related transcription factor 1 Antibody
  52. RUNX 1 Antibody
  53. Runx1 Antibody
  54. RUNX1 / AML1 Antibody
  55. RUNX1_HUMAN Antibody
  56. SL3 3 enhancer factor 1 alpha B subunit Antibody
  57. SL3-3 enhancer factor 1 alpha B subunit Antibody
  58. SL3/AKV core binding factor alpha B subunit Antibody
  59. SL3/AKV core-binding factor alpha B subunit Antibody
    		60.
    Information: Target information shown above is from the UniProt Consortium.
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