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Anti-HEC1 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-HEC1 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-HEC1 Antibody See all HEC1 primary antibodies
Description:	Rabbit polyclonal antibody to HEC1
Specificity:	HEC1 pAb detects endogenous levels of HEC1 protein.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the 388-433 of Human HEC1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 74 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Target

Function:	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule s in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).
Sequence Similarities:	Belongs to the NDC80/HEC1 family.
Post-Translational Modification:	Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
Cellular locations:	Nucleus. Chromosome > Centromere > Kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
Database Links:	Entrez Gene: 10403 Human Entrez Gene: 67052 Mouse Entrez Gene: 301701 Rat Omim: 607272 Human SwissProt: O14777 Human SwissProt: Q9D0F1 Mouse Unigene: 414407 Human Unigene: 225956 Mouse Unigene: 225213 Rat
Synonyms:	from Entrez Gene ; Antibody HEC Antibody HEC1 Antibody Highly expressed in cancer Antibody Highly expressed in cancer protein Antibody Highly expressed in cancer rich in leucine heptad repeats Antibody HsHec1 Antibody hsNDC80 Antibody Kinetochore associated 2 Antibody Kinetochore associated protein 2 Antibody Kinetochore protein Hec1 Antibody Kinetochore protein NDC80 homolog Antibody Kinetochore-associated protein 2 Antibody KNTC2 Antibody ndc80 Antibody NDC80 homolog kinetochore complex component Antibody NDC80 kinetochore complex component homolog Antibody NDC80, S. cerevisiae, homolog of Antibody NDC80_HUMAN Antibody Retinoblastoma associated protein HEC Antibody Retinoblastoma-associated protein HEC Antibody TID3 Antibody
Information:	Target information shown above is from the UniProt Consortium.