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Anti-SEPT6 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SEPT6 Antibody

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Name:	Anti-SEPT6 Antibody See all SEPT6 primary antibodies
Description:	Rabbit polyclonal antibody to SEPT6
Specificity:	The antibody detects endogenous levels of total SEPT6 protein.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100
Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human SEPT6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Function:	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular locations:	Cytoplasm. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere > Kinetochore. Cleavage furrow. Midbody. Cell projection > Cilium > Flagellum. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830).
Database Links:	Entrez Gene: 23157?Human Omim: 300683?Human SwissProt: Q14141?Human Unigene: 496666?Human
Synonyms:	KIAA0128 Antibody Nkrf Antibody RCG53214, isoform CRA_d Antibody RP5-876A24.2 Antibody SEP2 Antibody SEPT2 Antibody SEPT6 Antibody SEPT6/MLL FUSION GENE Antibody SEPT6_HUMAN Antibody Septin 2 Antibody Septin 6 Antibody Septin-6 Antibody
Information:	Target information shown above is from the UniProt Consortium.