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Anti-SEMA3A (P737) Antibody

品牌：Antibodies

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规格：50µl

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Anti-SEMA3A (P737) Antibody

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Overview

Name:	Anti-SEMA3A (P737) Antibody See all SEMA3A primary antibodies
Description:	Rabbit polyclonal antibody to SEMA3A (P737)
Specificity:	SEMA3A (P737) pAb detects endogenous levels of SEMA3A protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 702-756 of Human SEMA3A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 89 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
Involvement in Disease:	Hypogonadotropic hypogonadism 16 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Sequence Similarities:	Belongs to the semaphorin family.
Cellular locations:	Secreted.
Database Links:	Entrez Gene: 10371?Human Entrez Gene: 20346?Mouse Entrez Gene: 29751?Rat Omim: 603961?Human SwissProt: Q14563?Human SwissProt: O08665?Mouse SwissProt: Q63548?Rat Unigene: 252451?Human Unigene: 372039?Mouse Unigene: 44410?Rat
Synonyms:	Coll 1 Antibody Coll1 Antibody Collapsin 1 Antibody HH16 Antibody Hsema I Antibody Hsema III Antibody Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A Antibody sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Antibody Sema III Antibody SEMA1 Antibody SEMA1-PEN Antibody SEMA3A Antibody SEMAD Antibody SEMAIII Antibody SEMAL Antibody Semaphorin 3A Antibody Semaphorin 3A precursor Antibody Semaphorin III Antibody semaphorin L Antibody Semaphorin like growth cone guidance homolog of chick collapsin Antibody Semaphorin-D Antibody Semaphorin3A Antibody SemD Antibody
Information:	Target information shown above is from the UniProt Consortium.