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Anti-Rb (phospho-S807) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Rb (phospho-S807) Antibody

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Target

Function:	Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Tissue Specificity:	Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
Post-Translational Modification:	May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.
Cellular locations:	Nucleus. Nucleus speckle. Primarily, but not exclusively, nuclear.
Database Links:	Entrez Gene: 5511 Human Entrez Gene: 100336 Mouse Entrez Gene: 313030 Rat Omim: 602636 Human SwissProt: Q12972 Human SwissProt: Q8R3G1 Mouse Unigene: 533474 Human Unigene: 105230 Mouse Unigene: 16580 Rat
Synonyms:	Activator of RNA decay Antibody ARD 1 Antibody ARD-1 Antibody ARD1 Antibody Homolog of E.coli RNase E Antibody NIPP 1 Antibody NIPP-1 Antibody NIPP1 Antibody Nuclear inhibitor of protein phosphatase 1 Antibody nuclear inhibitor of protein phosphatase-1 alpha Antibody Nuclear subunit of PP1 Antibody PP1R8_HUMAN Antibody PPP1R8 Antibody PRO2047 Antibody Protein phosphatase 1 regulatory inhibitor subunit 8 Antibody Protein phosphatase 1 regulatory subunit 8 Antibody RNase E Antibody RNase E, E. coli, homolog of Antibody
Information:	Target information shown above is from the UniProt Consortium.