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Anti-PIM1 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-PIM1 Antibody

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Overview

Name:	Anti-PIM1 Antibody See all PIM1 primary antibodies
Description:	Rabbit monoclonal antibody to PIM1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse
Immunogen:	Recombinant protein of human PIM1.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocations of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
Tissue Specificity:	Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Post-Translational Modification:	Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.
Cellular locations:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 5292?Human Entrez Gene: 18712?Mouse Omim: 164960?Human SwissProt: P11309?Human SwissProt: P06803?Mouse Unigene: 81170?Human Unigene: 405293?Mouse Unigene: 485038?Mouse
Synonyms:	Oncogene PIM 1 Antibody Oncogene PIM1 Antibody PIM Antibody PIM 1 Antibody Pim 1 kinase Antibody pim 1 kinase 44 kDa isoform Antibody Pim 1 oncogene Antibody pim 1 oncogene (proviral integration site 1) Antibody PIM1 Antibody pim1 kinase 44 kDa isoform Antibody PIM1_HUMAN Antibody Pim2 Antibody PIM3 Antibody Proto oncogene serine/threonine protein kinase Pim 1 Antibody Proto-oncogene serine/threonine-protein kinase Pim-1 Antibody Proviral integration site 1 Antibody Proviral integration site 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.