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Anti-14-3-3 ζ (V52) Antibody

品牌：Antibodies

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规格：50µl

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Anti-14-3-3 ζ (V52) Antibody

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Name:	Anti-14-3-3 ζ (V52) Antibody See all 14-3-3 ζ primary antibodies
Description:	Rabbit polyclonal antibody to 14-3-3 ζ (V52)
Specificity:	14-3-3 ζ (V52) pAb detects endogenous levels of 14-3-3 protein zeta/delta.
Applications:	WB, IHC, IP, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 20-70 of Human 14-3-3 ζ.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 28 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Sequence Similarities:	Belongs to the 14-3-3 family.
Post-Translational Modification:	The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocations of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
Cellular locations:	Cytoplasm. Melanosome. Located to stage I to stage IV melanosomes.