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Anti-CHOP (K121) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CHOP (K121) Antibody

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Overview

Name:	Anti-CHOP (K121) Antibody See all CHOP primary antibodies
Description:	Rabbit polyclonal antibody to CHOP (K121)
Specificity:	CHOP (K121) pAb detects endogenous levels of CHOP protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 100-150 of Human CHOP.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 19,27 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP s in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Involvement in Disease:	Myxoid liposarcoma: A soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Ubiquitinated, leading to its degradation by the proteasome.
Cellular locations:	Cytoplasm. Nucleus. Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Database Links:	Entrez Gene: 1649?Human Entrez Gene: 13198?Mouse Entrez Gene: 29467?Rat Omim: 126337?Human SwissProt: P35638?Human SwissProt: P35639?Mouse SwissProt: Q62857?Rat Unigene: 505777?Human Unigene: 728989?Human Unigene: 110220?Mouse Unigene: 11183?Rat
Synonyms:	C/EBP homologous protein Antibody C/EBP Homology Protein Antibody C/EBP zeta Antibody C/EBP-homologous protein Antibody C/EBP-homologous protein 10 Antibody CCAAT/enhancer binding protein homologous protein Antibody CEBPZ Antibody CHOP Antibody CHOP 10 Antibody CHOP-10 Antibody CHOP10 Antibody DDIT 3 Antibody DDIT-3 Antibody DDIT3 Antibody DDIT3_HUMAN Antibody DNA Damage Inducible Transcript 3 Antibody DNA damage-inducible transcript 3 protein Antibody GADD 153 Antibody GADD153 Antibody Growth Arrest and DNA Damage Inducible Protein 153 Antibody Growth arrest and DNA damage inducible protein GADD153 Antibody Growth arrest and DNA damage-inducible protein GADD153 Antibody MGC4154 Antibody
Information:	Target information shown above is from the UniProt Consortium.