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Anti-Survivin (N111) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Survivin (N111) Antibody

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Overview

Name:	Anti-Survivin (N111) Antibody See all Survivin primary antibodies
Description:	Rabbit polyclonal antibody to Survivin (N111)
Specificity:	Survivin (N111) pAb detects endogenous levels of Survivin protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 81-130 of Human Survivin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 16 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locationss from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Tissue Specificity:	Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
Sequence Similarities:	Belongs to the IAP family.
Post-Translational Modification:	Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
Cellular locations:	Cytoplasm. Nucleus. Chromosome. Chromosome > Centromere. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere > Kinetochore. Midbody. Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.
Database Links:	Entrez Gene: 332?Human Entrez Gene: 11799?Mouse Entrez Gene: 64041?Rat Omim: 603352?Human SwissProt: O15392?Human SwissProt: O70201?Mouse SwissProt: Q9JHY7?Rat Unigene: 514527?Human Unigene: 8552?Mouse Unigene: 54471?Rat
Synonyms:	API4 Antibody Apoptosis inhibitor 4 Antibody Apoptosis inhibitor survivin Antibody Apoptosis inhibitor4 Antibody Baculoviral IAP repeat containing 5 Antibody Baculoviral IAP repeat containing protein 5 Antibody Baculoviral IAP repeat-containing protein 5 Antibody BIRC 5 Antibody BIRC5 Antibody BIRC5_HUMAN Antibody EPR 1 Antibody IAP4 Antibody Survivin Antibody Survivin variant 3 alpha Antibody SVV Antibody TIAP Antibody
Information:	Target information shown above is from the UniProt Consortium.