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Anti-Vimentin (I444) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Vimentin (I444) Antibody

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Overview

Name:	Anti-Vimentin (I444) Antibody See all Vimentin primary antibodies
Description:	Rabbit polyclonal antibody to Vimentin (I444)
Specificity:	Vimentin (I444) pAb detects endogenous levels of Vimentin protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 411-460 of Human Vimentin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 40, 57 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Tissue Specificity:	Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
Involvement in Disease:	Cataract 30: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 7431?Human Entrez Gene: 22352?Mouse Entrez Gene: 81818?Rat Omim: 193060?Human SwissProt: P08670?Human SwissProt: P20152?Mouse SwissProt: P31000?Rat Unigene: 455493?Human Unigene: 691131?Human Unigene: 268000?Mouse Unigene: 2710?Rat
Synonyms:	CTRCT30 Antibody Epididymis luminal protein 113 Antibody FLJ36605 Antibody HEL113 Antibody VIM Antibody Vimentin Antibody VIME_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.