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产品介绍
品名	Monoclonal Antibody to Human Factor P#1
货号	A233
规格	100 µL
同种型	IgG1k
蛋白质浓度	> 1.0 mg/mL
纯度	≥ 95% by SDS PAGE
缓冲液	Borate Buffered Saline (pH 8.4 ± 0.2)
物种交叉反应	None
储存	≤ 30 Days 2-8˚C  > 30 Days ≤ –20˚C
使用说明	For Research Use Only. Not for use in Diagnostic Procedures
产品描述	A murine monoclonal antibody to an epitope on Factor P. This monoclonal antibody was raised against purified Factor P. It inhibits the function of Factor P. Quidel's Factor P Monoclonal Antibody #1 has been used in a variety of experimental techniques including EIA
背景	The function of Properdin (Factor P) is to stabilize the alternative pathway convertase. Its binding to C3bBb extends the half-life of the complex. The concentration in plasma is approximately 20 μg/mL. Factor P has a molecular weight of 224 kDa, consisting of four identical chains of approximately 53 kDa molecular weight.  The alternative complement pathway provides innate protection against microbial agents in the absence of specific antibody. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells and cancer cells. In autoimmune diseases, the alternative complement pathway may contribute directly to tissue damage.
特异性	The specificity of the monoclonal antibody was established via ELISA and RIA. This antibody was shown to bind to highly purified Factor P, but not to C3, Factor B, Factor H, nor other isolated complement proteins. The antibody was also shown to immunoprecipitated radiolabeled Factor P, using protein A-bearing bacteria to capture the immune complex. The antibody was shown to inhibit the binding of radiolabeled Factor P to EC3b cells.
应用
参考资料	1、Shiraishi, M. et al. Improved hepatic microcirculation by human soluble urinary thrombomodulin in the xeno-perfused porcine liver. Transplantation 731:1046-1050 (2001).  2、Harboe, M. et al. The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol 189(5):2606- 2613 (2012)