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品牌：List Labs 

货号：191B

品名：List Labs Tetanus Toxoid from Clostridium tetani

中文名：破伤风毒素

规格：100 ug

形式：lyophilized powder

储存温度：2-8°C

描述：

Tetanus toxin is a potent neurotoxin (150,000 Da) produced by the anaerobic bacterium Clostridium tetani. 1 Intact toxin derived from culture supernatants consists of two polypeptide chains connected through an interchain disulfide bond. The larger of the two polypeptides, heavy chain (100,000 Da), contains the toxin's binding and translocations domains. The smaller of the two polypeptides, light chain (50,000 Da), is a protease which cleaves synaptobrevin 2, also known as VAMP 2.  Synaptobrevin 2 is a presynaptic, vesicle membrane associated protein that, in the presence of calcium, forms a stable complex with two plasma membrane attached proteins, syntaxin and SNAP25. Complex formation initiates fusion of transmitter containing vesicles with the plasma membrane. If synaptobrevin 2 is cleaved by tetanus toxin, fusion is prevented, and neurotransmitter release is inhibited. Tetanus toxin prefere

注：产品仅用于研究目的，不得用于人体或作为诊断剂。